Publication Title

Journal of Undergraduate Chemistry Research

Document Type


Publication Date

Summer 2005


Chaetomellic acid A is an alkyl dicarboxylic acid isolated from the fermentation of Chaetomella acutiseta. Chaetomellic acid A has been shown to be a potent, highly specific inhibitor of RAS farnesyl protein transferase (FPTase). The association between RAS proteins and cancer has made chaetomellic acd A a potential chemotherapeutic agent. Two novel chaetomellic acid A analogues have been prepared that incorporate aromoatic rings in the alkyl tail. It is anticipated that these compounds will bind more tightly to the FPTase active site than the natural product due to intermolecular interactions between the aromatic rings in the tail and the aromatic amino acid residues that have been shown to line the enzyme pocket.


NOTE: This is a PDF of the article as originally published in the Journal of Undergraduate Chemistry Research. It is archived here with the kind permission of the publisher. The original version was published as:

Mechelke, Mark F., Jacquelyn C. Webb, and Jessica L. Johnson (2005). "The Design and Synthesis of Novel Chaetomellic Acid A Analogues," Journal of Undergraduate Chemistry Research, Vol. 4, No. 3. Available to subscribers at

NOTE: Jacquelyn C. Webb and Jessica L. Johnson were students enrolled in CHEM 489 - Independent Study and conducted the research for this article under the guidance of Dr. Mark Mechelke.

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