Publication Title

Journal of Undergraduate Chemistry Research

Document Type

Article

Publication Date

Summer 2005

Abstract

Chaetomellic acid A is an alkyl dicarboxylic acid isolated from the fermentation of Chaetomella acutiseta. Chaetomellic acid A has been shown to be a potent, highly specific inhibitor of RAS farnesyl protein transferase (FPTase). The association between RAS proteins and cancer has made chaetomellic acd A a potential chemotherapeutic agent. Two novel chaetomellic acid A analogues have been prepared that incorporate aromoatic rings in the alkyl tail. It is anticipated that these compounds will bind more tightly to the FPTase active site than the natural product due to intermolecular interactions between the aromatic rings in the tail and the aromatic amino acid residues that have been shown to line the enzyme pocket.

Comments

NOTE: This is a PDF of the article as originally published in the Journal of Undergraduate Chemistry Research. It is archived here with the kind permission of the publisher. The original version was published as:

Mechelke, Mark F., Jacquelyn C. Webb, and Jessica L. Johnson (2005). "The Design and Synthesis of Novel Chaetomellic Acid A Analogues," Journal of Undergraduate Chemistry Research, Vol. 4, No. 3. Available to subscribers at http://www.vmi.edu/WorkArea/DownloadAsset.aspx?id=2236.

NOTE: Jacquelyn C. Webb and Jessica L. Johnson were students enrolled in CHEM 489 - Independent Study and conducted the research for this article under the guidance of Dr. Mark Mechelke.

Included in

Chemistry Commons

Share

COinS
 
 

To view the content in your browser, please download Adobe Reader or, alternately,
you may Download the file to your hard drive.

NOTE: The latest versions of Adobe Reader do not support viewing PDF files within Firefox on Mac OS and if you are using a modern (Intel) Mac, there is no official plugin for viewing PDF files within the browser window.