Date of Award
5-2024
Culminating Project Type
Thesis
Styleguide
apa
Degree Name
Biological Sciences - Cell and Molecular: M.S.
Department
Biology
College
College of Science and Engineering
First Advisor
Oladele Gazal
Second Advisor
Gengyun Le
Third Advisor
Ibrahim Soumare
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.
Keywords and Subject Headings
PCOS, Insulin resistance, Hunteria umbellata
Abstract
Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder, recognized as a leading cause of female infertility. It is characterized by hyperandrogenism, anovulation, and ovarian cysts, affecting multiple organ systems. Despite its impact, PCOS is poorly understood and lacks a cure. Current treatments primarily target associated issues such as insulin resistance but are often limited in efficacy and may have side effects, necessitating the exploration of new approaches like complementary medicine. This study investigated the benefits of Hunteria umbellata (HUE), a traditional antidiabetic herbal medicine, in a rat model of PCOS induced by a high-fat diet and testosterone propionate. Evaluations at 14, 28, and 56 days post-PCOS induction revealed dose- and time-dependent effects of HUE. PCOS was successfully induced in rats, exhibiting diagnostic characteristics such as hyperandrogenism, ovulation issues, and ovarian cysts. HUE treatment reduced ovarian cyst incidence, especially with prolonged high-dosage treatment. While metabolic disturbances were observed in all PCOS-induced groups, HUE effectively improved insulin resistance regardless of treatment duration or dosage. Evaluation of renal function showed an increase in kidney weights following PCOS induction, although other renal function parameters remained within normal ranges. Our findings highlight the potential therapeutic effect of HUE in managing PCOS, underscoring the need for further research to elucidate its mechanisms of action and explore its clinical applications in this condition.
Recommended Citation
Ineza, Nina, "Effects of Aqueous Extract of Hunteria umbellata on Hormonal, Metabolic, and Hematological Parameters of Polycystic Ovarian Syndrome in Sprague-Dawley Rat Model" (2024). Culminating Projects in Biology. 71.
https://repository.stcloudstate.edu/biol_etds/71
Comments/Acknowledgements
I would like to thank God for providing me with the strength and perseverance to complete my academic journey. Special thanks to Dr. Oladele Gazal, my advisor, for his mentorship, invaluable guidance, and support. I am also deeply appreciative of Dr. Gengyun Le, Dr. Ibrahim Soumare, and Dr. Felicia Leammukda for their expertise, assistance, and encouragement throughout the entire process. To my peers, your collaborative spirit and hands-on efforts were instrumental in making this work possible and were greatly appreciated. Lastly, I extend my heartfelt thanks to my loving family for their unwavering support, belief in me, and dedication. I could not have accomplished this without such a dedicated and supportive team by my side.