Date of Award
8-2000
Culminating Project Type
Thesis
Department
Kinesiology
College
School of Health and Human Services
First Advisor
John Seifert
Second Advisor
David Bacharach
Keywords and Subject Headings
D-ribose metabolism, purine nucleotide cycle, exercise recovery
Abstract
The purpose ofthis study was to investigate the effects ofD-ribose (RIB) on resting carbohydrate metabolism. Following a 12-hour fast, two groups of subjects, 20-30 year olds (Y, n = 6) and 40-50 year olds (0, n = 4), ingested 0, 2, 5, or 10 g RIB in 250 ml of water in a blinded counterbalanced manner (washout period 6.1 ± 2.8 d). Blood samples were collected at 0, 15, 30, 45, 60, and 120-min post-ingestion and analyzed for glucose (BG) and lactic acid (LA). Serum was analyzed for insulin (INS) at 0, 15, 30, 45, 60, and 120-min. Oxygen uptake and RER were measured via indirect spirometry at 0, 15, 45, and 75-min to estimate carbohydrate oxidation rate (CoXR), The dependent variables were subjected to repeated measures ANOV A. Tukey HSD post-hoc tests were differentiated means (P = 0.05).
BG was higher in O (3 .6 ± 0.1 mM/L) than Y (3 .1 ± 0.1 mM/L) (P = 0.001). At 45-min, BG with 10 g (2.4 ± 0.1 mM/L) was significantly different than BG with 2 g (3 .6 ± 0.1 mM/L) and O g (3 .3 ± rnM/L) (P < 0.05). At 60-min (3.6 ± 0.1 mM/L), BG with 10 g (2.5 ± 0.1 mM/L) was statistically different than 2 g (3 .6 ± 0.1 mM/L) (P < 0.05). Over time, 10 g at 0-min (3.6 ± 0.1 mM/L) was statistically different from 45-min (2.4 ± 0.1 mM/L) and 60-min (2.5 ± 0.1 mM/L) (P < 0.05). 10 g at 120-min (3 .5 ± 0.1 mM/L) differed from 10 g at 45-min (2.4 + 0.1 mM/L) and 60-min (2.5 ± 0.1 mM/L) (P < 0.05). 10 g at 15-min (3.4 + 0.1 rnM/L) differed significantly from 45-min (2.4 + 0.1 mM/L) (P < 0.05). Overall, INS at 15-min (3.4 ± 0.1 μIU/ml) was statistically different from 0-min (2.6 ± 0.1 μIU/ml), 45-min (2. 7 ± 0.1 μIU/ml), 60-min (2.4 ± 0.1 μIU/ml), and 120-min (2.5 ± 0.1 μIU/ml) (P < 0.05). At 60-min (1.2 ± 0.04 mM/L) and 120-min (0.9 ± 0.1 mM/L), Y had higher LA than O (P < 0.05). Significant differences in LA were observed for 0-min (1.1 ± 0.1 mM/L) and 120-min (0.8 ± 0.1 mM/L) in O (P < 0.05). No significant differences were observed for CoXR- Ingestion of 2g and 5g of ribose maintained BG and INS, but did not affect LA or CoXR-
Recommended Citation
Fenstad, Eric, "D-Ribose: Effect on Carbohydrate Metabolism" (2000). Culminating Projects in Kinesiology. 28.
https://repository.stcloudstate.edu/pess_etds/28
